在长途飞行中无症状深静脉血栓的发生频率和预防:一项随机试验
J H Scurr1, S J Machin, S Bailey-King
1Department of Surgery, Royal Free and University College Medical School, London, UK. medleg@mailbox.co.uk
Lancet (London, England)
|May 30, 2001
概括
深静脉血栓塞 (DVT) 可能影响长途旅行者的高达10%. 佩戴渐变弹性压缩显著降低了在航空旅行期间发展DVT的风险.
科学领域:
- 血管医学 血管医学
- 旅行 医学 旅行 医学
- 血栓形成的研究研究
背景情况:
- 深静脉血栓塞 (DVT) 是一个已知的风险在长期不动.
- 在长途航空旅行中DVT的确切发病率仍未确定.
- 这项研究调查了经济乘客的DVT频率和预防.
研究的目的:
- 为了确定长途航班乘客下肢DVT的发病率.
- 评估渐变弹性压缩在预防DVT方面的有效性.
- 为了确定航空旅客中DVT的潜在风险因素.
主要方法:
- 招募了231名50岁以上没有先前血栓塞栓症的乘客 (89名男性,142名女性) 的队列.
- 参与者被随机分配到穿或不穿I类膝下渐变弹性压缩.
- 进行了双重超声波,D-二次测定和基因分析,以检测V因子Leiden和Prothrombin G20210A突变.
主要成果:
- 没有症状的小腿DVT发生在10% (12/116) 没有穿压缩的乘客中.
- 在穿着渐变弹性压缩的组中没有观察到任何DVT病例 (95% CI 0-3.2%).
- 四名穿着子的乘客患上了表面性血栓炎,其中一名患有V因子Leiden和Prothrombin G20210A突变.
结论:
- 无症状的DVT是一个很大的风险,可能会影响长途航空旅客的10%.
- 渐变弹性压缩显示出在减少空中旅行期间DVT的发生率方面的有效性.
- 进一步的研究可能会探索与航空旅行相关的DVT的遗传倾向和其他风险因素.
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