在人体冠状动脉血流储备的非侵入性量化,使用心肌对比性心脏回声学
1Cardiac Imaging Center and the Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, VA, USA. kw6n@virginia.edu
Circulation
|May 31, 2001
概括
心肌对比回声心脏图 (MCE) 不侵入地量化了人类冠状动脉血流 (CBF) 储备. 这种技术可以准确地评估冠状动脉狭窄的严重程度,并检测出微血管功能障碍.
科学领域:
- 心脏病学 心脏病学
- 诊断成像 诊断成像 诊断成像
- 生理学 生理学 生理学
背景情况:
- 冠状动脉血流 (CBF) 储备评估对于诊断心血管疾病至关重要.
- 在临床实践中,量化CBF储备的非侵入性方法非常可取.
研究的目的:
- 调查使用心肌对比回声学 (MCE) 来对人类的CBF储备进行非侵入性量化是否可行.
- 将MCE衍生测量与侵入性方法进行比较,并评估它们与冠状动脉狭窄症严重程度的相关性.
主要方法:
- 定量冠状动脉血管学,MCE和冠状动脉血流 (CBF) 速度测量在11名冠状动脉正常的患者和19名冠状动脉狭窄的患者中进行.
- 在休息状态和静脉注射腺注射期间进行测量,以评估高血压引起的流量变化.
主要成果:
- 由MCE衍生的心肌动脉血流 (MBF) 速度储备与健康个体用多普勒流线测量的CBF速度储备密切相关.
- 在冠状动脉狭窄症的严重程度增加的患者中,MBF速度储备显著减少.
- 在MCE衍生和多普勒衍生流速储量之间观察到强烈的线性关系,在狭窄严重程度和速度储量之间观察到曲线性关系.
结论:
- 心肌对比回声心脏图 (MCE) 提供了一种可靠的非侵入性方法来测量人类冠状动脉血流 (CBF) 储备.
- MCE有可能非侵入性地评估冠状动脉狭窄症的严重程度并识别微血管功能障碍.
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