增加颗粒物空气污染和引发心肌梗塞
A Peters1, D W Dockery, J E Muller
1Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA.
Circulation
|June 13, 2001
概括
细颗粒物空气污染可能引发心脏病发作 (心肌梗塞或心脏病发作). 在症状出现前数小时或一天内暴露于PM2.5度升高会增加心脏病发作风险.
科学领域:
- 环境健康 环境健康
- 心血管流行病学心血管流行病学
- 空气污染研究研究
背景情况:
- 环境颗粒物空气污染与心血管疾病住院治疗有关.
- 高环境颗粒度与急性心肌梗塞 (MI) 发作之间的特定联系以前是未知的.
研究的目的:
- 调查环境细颗粒的高度是否会引发急性心肌梗塞 (MI) 的发生.
主要方法:
- 一项涉及大波士顿地区772名心脏病患者的病例交叉研究.
- 细颗粒物 (PM2.5),碳黑和气体污染物的每小时度.
- 使用案例交叉方法分析数据,以评估在MI发作前2小时和24小时窗口内的触发效应.
主要成果:
- 升高的PM2.5度与在2小时内发生心脏病发作的风险增加有关.
- 观察到一种延迟的关联,与24小时平均PM2.5暴露1天前症状发作相关的MI风险增加.
- 多变量分析显示,短期 (2小时) 和延迟 (24小时) PM2.5 暴露的几率比率显著.
结论:
- 高度的细颗粒物空气污染度可能暂时增加心肌梗塞的风险.
- 研究结果表明,空气污染是潜在的可预防性心脏病发作触发因素.
- 为了证实这些发现,需要在不同地点进行进一步的研究.
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