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CC化基因受体5和移植存活率

M Fischereder¹, B Luckow, B Hocher

¹Medizinische Poliklinik, Klinikum der Universität München, Pettenkoferstrasse 8a, D-80336, München, Germany.

Lancet (London, England)

|June 14, 2001

概括

患有CCR5-Delta 32基因突变的个体显著改善了移植生存率. 这种CCR5基因变异为预防移植排斥和改善患者结果提供了一个有希望的途径.

科学领域:

免疫遗传学免疫遗传学
移植免疫学移植免疫学
药物基因组学药物基因组学

背景情况:

CC化学受体5 (CCR5) 在移植排斥中发挥作用,具有特定的删除 (CCR5Delta32) 导致不活跃的受体.
在移植排斥过程中,CCR5配体的升级,吸引CCR5阳性细胞进入移植物.
CCR5Delta32等位基因存在于大约1%的白人人口中.

研究的目的:

研究CCR5Delta32基因删除对移植患者存活率的影响.
为了确定CCR5Delta32是否会影响移植排斥率或移植损失.

主要方法:

来自1227名移植接受者的基因组DNA使用PCR分析了CCR5Delta32突变.
收集了临床和人口统计数据,对576名首次接受者进行了完整的随访.
使用费舍尔的精确测试和卡普兰-梅尔图片用日志等级测试分析了移植存活率.

主要成果:

21名患者 (1.7%) 对CCR5Delta32.3具有同位素.
与对照组相比,在CCR5Delta32同卵同胞的患者中,移植存活时间显著更长 (日志排名p=0.033).
在CCR5Delta32同组中,移植损失的危险比为0.367 (95% CI 0.157-0.859).

结论:

对CCR5Delta32的同卵性与移植存活率的提高有关.
这些发现表明CCR5在移植损失中具有关键的病理生理作用.
向CCR5可能是预防移植衰竭的新策略.

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