在接受冠状动脉血管塑性手术的患者中,酸甘具有延迟的预条件模仿作用
M A Leesar1, M F Stoddard, B Dawn
1Division of Cardiology, University of Louisville, and Jewish Hospital Heart and Lung Institute, Louisville, KY, USA.
Circulation
|June 20, 2001
概括
在血管造形术前24小时服用酸甘油 (NTG),可以保护人体心肌免受缺血. 这项研究是第一个在人类中显示晚期缺血预条件的药理学模仿,这表明酸盐可能会保护心脏病患者.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 缺血性心脏病是一种心脏病.
背景情况:
- 实验研究表明,药理学剂可以模仿晚期缺血预条件 (PC).
- 由于缺乏人体研究,晚期PC的心脏保护作用的临床应用是有限的.
- 之前没有任何药物被测试其诱导人类晚期PC效应的能力.
研究的目的:
- 为了研究酸甘 (NTG) 是否可以在药理上模仿人类缺血预先调节的晚期阶段.
- 评估NTG在皮肤透光冠状动脉血管塑造手术 (PTCA) 程序前24小时的心脏保护作用.
主要方法:
- 66名患者被随机分配,接受静脉内NTG或盐溶液输液4小时.
- 第二天,患者接受了PTCA,进行了三次2分钟气球膨胀.
- 通过ST细分移动,区域壁运动和胸痛得分来评估心脏保护.
主要成果:
- 在PTCA注射24小时前的NTG输液使心肌抵抗缺血.
- NTG的心脏保护作用与缺血性PC的早期阶段相当.
- 在NTG治疗组和对照组之间没有观察到抵押资金流量的显著差异.
结论:
- 酸甘油可以在服用后长达24小时内保护人体心肌缺血.
- 这项研究提供了第一个证据,证明了药理学上诱导的人类晚期预条件效应.
- 预防性酸盐的使用可能是保护患者缺血性心肌的新策略.
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