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相关概念视频

Neural Regulation01:37

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
Restless Leg Syndrome and Night Terrors01:27

Restless Leg Syndrome and Night Terrors

Restless Leg Syndrome (RLS), also known as Willis-Ekbom disease, is a neurological disorder characterized by an uncontrollable urge to move the legs due to uncomfortable sensations. These sensations typically occur during periods of rest or inactivity, particularly when lying down or sitting, and can severely disrupt sleep.
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
Nightmares and Night Terrors01:18

Nightmares and Night Terrors

Nightmares and night terrors represent two distinct types of sleep disturbances that differ in timing, characteristics, and the sleeper's recall of the event. Nightmares are vivid, disturbing dreams that usually awaken the sleeper from REM sleep, a stage of sleep where brain activity is high, and dreams are most frequent. Upon awakening, individuals often have detailed recollections of their nightmares, which can include themes of threats to survival, security, or self-esteem.
Nightmares often...

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相关实验视频

Updated: Jun 30, 2026

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice
08:58

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice

Published on: June 19, 2019

在状细胞疾病中,夜间低氧化和中枢神经系统事件.

F J Kirkham1, D K Hewes, M Prengler

  • 1Neurosciences Unit, Institute of Child Health, University College London, London, UK. F.kirkham@ich.ucl.ac.uk

Lancet (London, England)
|June 27, 2001
PubMed
概括

夜间低氧化,而不是传统方法,更好地预测状细胞疾病中中枢神经系统事件. 管理夜间低氧和度可以预防中风和发作.

科学领域:

  • 神经学 神经学
  • 血液学 血液学 血液学
  • 睡眠医学 睡眠医学

背景情况:

  • 中枢神经系统 (CNS) 事件,如中风和发作在状细胞疾病中很常见.
  • 经骨多普勒超声波可以通过测量高动脉速度来预测中风风险.
  • 对于状细胞疾病中中枢神经系统事件的夜间低氧血的预测价值需要进一步研究.

研究的目的:

  • 测试这一假设:夜间低氧化是状细胞疾病中中枢神经系统事件的更好的预测因素,而不是临床特征,血液学标记或经多普勒发现.
  • 评估一夜间氧气和和中枢神经系统事件的发生率之间的关联.
  • 为了比较夜间低血的预测能力与动脉速度测量.

主要方法:

  • 对95名患有状细胞病的住院患者 (平均年龄7.7岁) 进行了查,这些患者以前没有中风.
  • 患者接受了间多普勒超声波和夜间脉冲氧计.
  • 随访时间中位数为6.01年,以监测中枢神经系统事件.

主要成果:

  • 19名患者经历了中枢神经系统事件,包括缺血性和出血性中风,过渡性缺血性发作和发作.
  • 较低的夜间平均氧和度 (SaO2) 和更高的内动脉或中脑动脉速度独立地与中枢神经系统事件发生的时间有关.

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A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
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A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

Transmission Electron Microscopy as the Visualization Technique for Analysis of Circadian Synaptic Plasticity in the Mouse Barrel Cortex
12:06

Transmission Electron Microscopy as the Visualization Technique for Analysis of Circadian Synaptic Plasticity in the Mouse Barrel Cortex

Published on: August 19, 2025

相关实验视频

Last Updated: Jun 30, 2026

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice
08:58

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice

Published on: June 19, 2019

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

Transmission Electron Microscopy as the Visualization Technique for Analysis of Circadian Synaptic Plasticity in the Mouse Barrel Cortex
12:06

Transmission Electron Microscopy as the Visualization Technique for Analysis of Circadian Synaptic Plasticity in the Mouse Barrel Cortex

Published on: August 19, 2025

  • 高血红蛋白度也与中枢神经系统事件的风险增加相关,独立于SaO2和动脉速度.
  • 结论:

    • 夜间缺氧是状细胞疾病中中枢神经系统事件的重要预测因素.
    • 查和管理夜间低氧症可能为预防中枢神经系统事件的初级预防提供预防性输血的安全有效替代方案.
    • 阻塞性睡眠呼吸暂停指标没有预测中枢神经系统事件,而且腺切除术的影响仍然不确定.