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相关概念视频

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Transduction01:16

Transduction

Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome are...

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相关实验视频

Updated: Jun 18, 2026

Murine Skin Transplantation
06:42

Murine Skin Transplantation

Published on: January 16, 2008

在移植耐受性方面的进展.

X Yu1, P Carpenter, C Anasetti

  • 1Human Immunogenetics Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Lancet (London, England)
|June 27, 2001
PubMed
概括
此摘要是机器生成的。

目前的免疫抑制药物可以改善器官移植的存活率,但不能诱导耐受性. 针对T细胞死亡和失活的新策略对于实现长期移植耐受性至关重要.

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Murine Full-thickness Skin Transplantation
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Murine Full-thickness Skin Transplantation

Published on: January 2, 2017

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

相关实验视频

Last Updated: Jun 18, 2026

Murine Skin Transplantation
06:42

Murine Skin Transplantation

Published on: January 16, 2008

Murine Full-thickness Skin Transplantation
07:59

Murine Full-thickness Skin Transplantation

Published on: January 2, 2017

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

科学领域:

  • 免疫学 免疫学 免疫学
  • 移植科学 移植科学

背景情况:

  • 随着最近的免疫抑制药物,器官异位移植的存活率有所改善,但终身药物治疗仍然是必要的.
  • 移植拒绝涉及T细胞激活,抗原识别和辅助信号,T细胞死亡是关键的耐受机制.

研究的目的:

  • 探索不同的免疫抑制药物如何影响T细胞介导移植耐受性.
  • 通过防止T细胞死亡来抑制耐受性的药物和促进它的药物之间进行区分.

主要方法:

  • 对T细胞激活,抗原识别和辅助信号通路的分析.
  • 对T细胞死亡 (细胞灭绝) 和T细胞不响应 (无能) 药物影响的评估.

主要成果:

  • 诱导T细胞死亡的mycophenolate mofetil等药物可以促进耐受性.
  • 抑制T细胞分裂 (例如,用拉巴胺) 或辅助刺激 (例如,阻断CD28/CD154) 可以导致T细胞不响应并促进耐受性.

结论:

  • 了解T细胞死亡和失活机制对于开发实现移植耐受性的策略至关重要.
  • 针对特定的T细胞通路提供了一个有希望的途径,超越目前的免疫抑制,实现长期的移植接受.