人体腹腔复极化的心电图学动态中的性二态:在真实时间域中的表征
1Department of Internal Medicine, Division of Cardiology, University of Michigan and Veterans Administration Medical Center, Ann Arbor, Michigan, USA.
Circulation
|July 4, 2001
概括
男性表现出比女性更的空间ST-T向量电压轨迹,从J点开始. 通过心电图 (ECG) 测量腹腔再极化动态的这些性别差异可能为心脏病提供新的见解.
科学领域:
- 心脏病学 心脏病学
- 生理学 生理学 生理学
- 生物医学工程 生物医学工程
背景情况:
- 关于ST-T波形电压的性别差异的先前研究集中在幅度上,可能因心率变化而扭曲.
- 依赖JT规范化的时间尺度可能会掩盖真正的再极化动态.
研究的目的:
- 在心室再极化过程中调查空间ST-T向量电压轨迹的性别差异.
- 分析空间向量的瞬间斜率 (dV/dt) 和幅度 (ST-T) 在精确的时间间隔.
主要方法:
- 553名正常成年人 (426名男性) 的数字化12导电心电图,心率控制 (60,70,80bpm).
- 在J点以后的4ms间隔下推导空间向量幅度 (ST-T(XYZ)) 和瞬间斜率 (dV/dt(XYZ)) .
- 利用多重回归分析考虑年龄和左心室质量.
主要成果:
- 从J点开始,两性之间ST-T (XYZ) 轨迹的早期显著分歧.
- 在ST段期间,男性的dV/dt (XYZ) 增加了2-3倍,最大T (XYZ) 和dV/dt (XYZ) 值也增加了.
- 在男性中,下降的T ((XYZ) 肢体更,极端和心率之间的关系是逆的.
结论:
- 空间ST-T矢量电压时间轨迹在男性比女性更,在生理心率,从J点开始.
- 性别特定的ST-T ((XYZ) 和dV/dt ((XYZ) 动态表明在心室再极化病理生理学研究中具有潜在的实用性.
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