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Updated: Jul 20, 2026

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在ES细胞和克隆小鼠中的表观遗传不稳定性

D Humpherys1, K Eggan, H Akutsu

  • 1Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge MA 02142, USA.

Science (New York, N.Y.)
|July 7, 2001
PubMed
概括

克隆小鼠表现出广泛的基因表达错误,即使它们看起来健康. 哺乳动物的发育能够容忍表观遗传变化,但在克隆动物中可能会存在微妙的异常.

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Maintenance of the ES Cell State01:14

Maintenance of the ES Cell State

The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...