自我耐受性和自身免疫性疾病治疗的途径
1Australian Cancer Research Foundation, Genetics Laboratory, Medical Genome Centre, John Curtin School of Medical Research, Australian National University, Canberra, Australia.
Lancet (London, England)
|July 11, 2001
概括
了解对抗原的免疫反应是开发新疗法的关键. 目前的治疗方法,如环素和皮质类固醇有局限性,而新的策略旨在通过准特定的信号通路来建立免疫耐受性.
科学领域:
- 免疫学 免疫学 免疫学
- 免疫治疗是一种免疫疗法.
背景情况:
- 暴露于抗原会启动复杂的免疫反应,整合免疫原和耐受原信号.
- 目前的免疫治疗药物在建立免疫耐受性方面存在局限性.
- 了解共刺激途径对于开发新治疗方法至关重要.
研究的目的:
- 绘制免疫信号通路的地图,以便更好地了解免疫疗法.
- 确定免疫反应治疗干预的新目标.
- 探索积极建立免疫耐受性的策略.
主要方法:
- 对抗原信号通路的分析.
- 评估目前的免疫治疗药物 (环素,塔克罗利斯,皮质类固醇).
- 研究针对共刺激途径 (CD40联体,B7,IL-2) 和抗原受体的新型治疗策略.
主要成果:
- 西克洛斯波林和塔克罗利斯破坏了免疫原和耐受原信号,阻碍了耐受性.
- 皮质类固醇抑制NFkappaB通路,提供耐受性诱导的潜力.
- 针对抗原受体或共刺激途径的实验性疗法由于信号的双重作用,显示出不可预测的结果.
结论:
- 目前的疗法在积极建立免疫耐受性方面存在局限性.
- 针对NFkappaB等特定途径可能使耐受性诱导成为可能.
- 新的策略需要仔细考虑有效免疫治疗的信号通路的双重免疫原和耐受原作用.
相关概念视频
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