血小板糖蛋白IIIa Pl(a) 多态性,纤维原和血小板聚合性:弗雷明汉心脏研究
D Feng1, K Lindpaintner, M G Larson
1Institute for Prevention of Cardiovascular Disease, Beth Israel Deaconess Medical Center, Boston, MA, USA. dfeng2@caregroup.harvard.edu
血纤维素水平会增加血小板聚合,但这种效果取决于Pl(A) 基因型. 这种基因与环境的相互作用可能解释了与PlA2等位基因相关的有关心血管疾病风险的相互矛盾的发现.
科学领域:
- 心血管遗传学 心血管遗传学
- 血小板生物学 血小板生物学
- 基因与环境的相互作用
背景情况:
- 血小板糖蛋白IIIa受体的Pl(A2) 等位基因是潜在的心血管疾病风险因素.
- 之前关于Pl(A2) 和血小板聚合性的研究结果是相互矛盾的,有些人显示聚合的增加,而另一些人则显示纤维素原结合的减少.
- 纤维素原是血小板聚合的关键媒介.
研究的目的:
- 调查血纤维素水平与Pl(A) 基因型相互作用,调节血小板聚合能力的假设.
- 澄清Pl(A) 基因型,纤维素水平和血小板功能在心血管疾病风险中的关系.
主要方法:
- 在1340名弗雷明翰后代研究参与者中评估了Pl(A) 基因型,血纤维素水平和血小板聚合能力.
- 使用Born方法测量血小板聚合能力,评估上腺素和ADP诱导的聚合.
- 分析了纤维素素水平和Pl(A) 基因型对血小板聚合的相互作用.
主要成果:
- 较高的血纤维素水平与上腺素诱导的血小板聚合增加相关 (P=0.002) 和ADP诱导的聚合趋势 (P=0.07).
- 纤维素原和血小板聚合之间的这种关联是特定于PlA1/A1的基因型 (上腺素P=0.0005,ADPPP=0.03).
- 在PL-A2阳性个体 (P>0.90) 中,没有观察到纤维素素水平和血小板聚合之间的显著关联.
结论:
- 血纤维素水平升高可以提高血小板的聚合能力.
- 纤维素原对血小板聚合的影响取决于个体的Pl (A) 基因型.
- 这种基因型特异性基因与环境的相互作用可能使Pl (A) 样基因和血小板功能的相互矛盾的发现得到协调,为心血管疾病的发病过程提供了洞察力.
更多相关视频
07:26High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
Published on: July 18, 2017
04:32A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry
Published on: June 5, 2019
相关概念视频
Intracellular Signaling Affects Focal Adhesions
Some...
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Structure and Function of Platelets
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Formation of the Platelet Plug
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
Clot Retraction and Fibrinolysis
