预期特征的血小板反应性:通过皮肤冠状动脉干预90天后的结果的决定因素
S S Kabbani1, M W Watkins, T Ashikaga
1Department of Medicine, The University of Vermont College of Medicine, Burlington, VT, USA. samerk@pol.net
Circulation
|July 12, 2001
概括
评估血小板糖蛋白IIb/IIIa激活可以识别皮肤冠状动脉干预 (PCI) 后患有不良事件高风险的患者. 这有助于对患者进行分层,以便更好地评估和管理PCI后的风险.
科学领域:
- 心血管医学 心血管医学
- 血液学 血液学 血液学
- 干预心脏病学 干预心脏病学
背景情况:
- 血小板激活在穿皮冠状动脉干预 (PCI) 并发症中至关重要.
- 之前的研究显示了糖蛋白 (GP) IIb/IIIa激活的变化.
- 对于腺二酸盐 (ADP),GP IIb/IIIa激活的个体间差异被发现.
研究的目的:
- 为了对GP IIb/IIIa激活进行前性评估.
- 为了确定GP IIb/IIIa激活是否区分PCI后的低风险和高风险患者.
- 根据血小板反应性来评估早期和晚期并发症风险.
主要方法:
- 研究了112名接受PCI的患者.
- 使用流细胞计测量测量血小板反应性.
- 根据GP IIb/IIIa激活反应对0.2微摩尔/升ADP的反应,将患者分为高反应性和低反应性组.
主要成果:
- 高血小板反应率组的复合终点发生率为26.8%,低反应率组为7.1% (P=0.01).
- 在PCI后30-90天 (16.7%与1.9%,P=0.02) 之间,差异显著.
- 在高反应性组 (17.9%对3.6%,P=0.029) 中,重复复血管化更高.
结论:
- 对血小板GP IIb/IIIa激活的前性评估分层患者.
- 这种分层识别了PCI后不良事件的低风险和高风险的患者.
- 血小板激活水平可以预测PCI后的并发症.
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