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Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
Published on: October 16, 2010
在高血压患者内皮功能障碍的预后意义
F Perticone1, R Ceravolo, A Pujia
1Internal Medicine and Cardiovascular Diseases Unit, Department of Medicina Sperimentale e Clinica "G. Salvatore," University of Catanzaro Magna Graecia, Catanzaro, Italy. perticone@unicz.it
Circulation
|July 12, 2001
概括
前臂内皮功能障碍预测高血压患者未来的心血管事件. 血管反应受损表明心脏病发作和中风的风险更高.
科学领域:
- 心血管医学 心血管医学
- 血管生物学 血管生物学
- 高血压研究 高血压研究
背景情况:
- 前臂内皮功能障碍,以降低对乙胆 (ACh) 的血管扩张为标志,与诸如基本高血压等心血管风险因素有关.
- 虽然冠状动脉内皮功能障碍的预后值是已知的,前臂内皮功能障碍的预测作用仍然不清楚.
- 基本高血压是一个重要的心血管风险因素,影响血管健康.
研究的目的:
- 调查前臂内皮功能障碍在预测未来心血管事件中的预后价值.
- 在从未治疗过的高血压患者中评估内皮依赖血管扩张和主要不良心血管事件之间的关系.
主要方法:
- 乙胆和酸的动脉内输注,以测量内皮依赖和独立的血管扩张.
- 根据前臂血流 (FBF) 对 ACh.Ch.反应对225名从未接受过治疗的高血压患者进行分类.
- 长度随访平均为31.5个月,以记录主要的不良心血管事件.
主要成果:
- 在ACH刺激的FBF增加的最低三位数中观察到显著更高的事件率 (8.17/100患者年).
- 最低FBF响应三位数的患者患主要心血管不良事件的风险增加了2084倍.
- 这种关联在调整其他心血管风险标志物 (包括门诊血压) 后仍然显著.
结论:
- 前臂内皮功能障碍是预测未来心血管事件的重要标志物,在患有基本高血压的个体中.
- 缺陷前臂血管扩张是心脏,脑血管和外周血管不良结果的独立预测因素.
- 这些发现凸显了高血压患者内皮功能评估风险分层的临床重要性.
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