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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis
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在实验性动脉样硬化病变中检测单细胞化学吸引蛋白-1受体表达:一项自身放射学研究.

K Ohtsuki1, M Hayase, K Akashi

  • 1Division of Nuclear Medicine, Department of Radiology, Stanford University School of Medicine, Stanford, CA, USA.

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|July 12, 2001
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概括

放射性标记的单细胞化学吸引1 (MCP-1) 有效地识别了富含单细胞和巨细胞的实验性动脉样硬化病变. 这种标志物显示出在动脉疾病中成像这些炎症细胞的有希望的潜力.

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科学领域:

  • 心血管研究研究心血管研究
  • 分子成像学分子成像学
  • 免疫学 免疫学 免疫学

背景情况:

  • 单细胞是动脉瘤形成的关键参与者,在化学吸引剂信号的引导下迁移到病变部位.
  • 单细胞化学吸引1 (MCP-1) 是一个主要的信号,吸引单细胞到动脉样硬化病变.

研究的目的:

  • 评估在实验性动脉病变中使用放射性标记的MCP-1作为标记器用于识别单细胞和巨细胞积累的可行性.
  • 在体内评估放射性标记MCP-1的生物分布和局部化.

主要方法:

  • 放射性标记的 (125) I-MCP-1 给正常小鼠和胆固醇养的子用实验性动脉损伤.
  • 血管生物分布通过自发射成像,以及组织学和免疫组织化学分析 (RAM-11抗体) 来评估.
  • 埃文斯的蓝色染料被用来划分脱骨化的区域.

主要成果:

  • (125) I-MCP-1 显示出短时间的血液清除半衰期 (大约. 10分钟) 和局部在肝脏,肺和脏.
  • 自动放射学显示,在受损的动脉壁中 (125) I-MCP-1 的显著积累 (损伤与血管的比率高达 45:1).
  • 标记物吸收与巨细胞密度 (r=0.85,P<0.0001) 有很强的相关性,并且在斑块区域比脱内皮化区域更高.

结论:

  • 放射性标记的MCP-1在富含单细胞/巨细胞的实验性动脉样硬化病变中显示出有效的局部化.
  • 这种标记物有可能用于动脉样硬化炎症炎症细胞透的非侵入性成像.
  • 进一步的研究可能会验证其在临床环境中用于诊断和监测动脉样硬化疾病的使用.