具有α-基拉,芳香侧链的类寡合体:稳定类螺旋体形成的序列要求
1Department of Chemical Engineering, Northwestern University, Evanston, Illinois 60208, USA.
Journal of the American Chemical Society
|July 13, 2001
概括
当N被特定的侧链替代时,Oligo-N替代的甘氨酸 (peptoids) 可以形成稳定的合螺旋. 至少50%的奇拉芳香残留物和C端的奇拉残留物是稳定的状螺旋形成的关键.
科学领域:
- 合成化学 合成化学
- 超分子化学 超分子化学
- 生物材料是一种生物材料.
背景情况:
- 以Oligo-N替代的甘氨酸 (类) 缺乏脊柱键,阻碍了α-螺旋结构的形成.
- 具有特定N替代性性,芳香侧链的体可以形成稳定,性,聚类螺旋体.
- 这些状螺旋表现出强烈的圆形二元化 (CD) 光谱,类似于类α螺旋.
研究的目的:
- 研究影响稳定peptoid螺旋形成的序列相关因素.
- 确定螺旋结构所需的性芳香残留物最小百分比.
- 确定稳定这些性形螺旋体的序列动图.
主要方法:
- 合成和表征30多种异构分子类.
- 循环二重化 (CD) 光谱法用于评估螺旋结构.
- 1H-13C HSQC NMR研究分析结构和稳定性.
主要成果:
- 对于稳定的螺旋结构来说,至少50%的alpha-chiral,芳香残留物是必要的.
- 在carboxy终点处的一种性芳香残留物显著稳定了短的peptoid螺旋.
- 用三倍的周期性对芳香残留物的图案创建了一个"芳香面",进一步稳定了螺旋.
- 链条长度超过12-15个残留物减少了残留物放置的影响,但不是对稳定性的百分比.
结论:
- 稳定的状螺旋结构可以通过战略侧链工程设计在类寡合体中.
- 阿尔法-奇拉,芳香残留物的百分比和位置是螺旋形形体的关键设计元素.
- 这些发现为设计具有可预测的二次结构的仿生类动物提供了洞察力.
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