从中枢神经系统神经元中通过干扰素 - 玛介导的alphavirus的局部特异性清除
1W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Science (New York, N.Y.)
|July 14, 2001
概括
病毒性脑膜炎的恢复取决于免疫细胞从神经元中清除病毒. T细胞,特别是CD4和CD8,对于清除Sindbis病毒RNA从某些神经元中至关重要,利用干扰素-.
科学领域:
- 神经免疫学 神经免疫学
- 病毒学 病毒学
- 细胞免疫学 细胞免疫学
背景情况:
- 病毒性脑膜炎的恢复依赖于免疫介导的,来自神经元的非细胞分解性病毒清除.
- 抗体从中枢神经系统 (CNS) 中清除感染性阿尔法病毒,而CD8 T细胞则消除病毒RNA.
研究的目的:
- 为了研究T细胞在神经元中的病毒清除中的特异性作用,在阿尔法病毒脑膜炎.
- 为了确定神经元清除机制是否在所有中枢神经系统区域均.
主要方法:
- 用Sindbis病毒感染抗体淘汰小鼠以隔离T细胞介导清除.
- 利用细胞因子表达的重组病毒来评估特定的T细胞效应因子通路 (干扰素-玛,瘤亡因子α) 的作用.
主要成果:
- 从脊髓和脑干神经元的病毒清除在抗体淘汰小鼠中观察到,但不是从皮质神经元.
- 在这些地区, CD4 和 CD8 T 细胞都需要用于病毒清除.
- 干扰因子-,但不是瘤亡因子α,被确定为参与病毒清除的关键T细胞效应因子细胞因子.
- 突出了神经元群体对T细胞效应因子通路的不同反应.
结论:
- 从神经元中通过T细胞介导的病毒清除是中枢神经系统内的特定区域.
- CD4和CD8T细胞在清除病毒RNA中发挥着不同的但至关重要的作用,特别是在特定的神经元群体中.
- 干扰素-是T细胞依赖病毒清除的关键调解者,神经元敏感性在中枢神经系统中有所不同.
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