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Updated: Jun 21, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

通过由寡酸替代的多聚诺基酶抑制细胞对纤维内克的粘附

H D Maynard1, S Y Okada, R H Grubbs

  • 1Arnold and Mabel Beckman Laboratories of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

Journal of the American Chemical Society
|July 18, 2001
PubMed
概括

结合特定序的新型聚合物显著抑制细胞粘附. 具有多种类型的共聚物体显示出增强的生物活性,证明了聚合物材料在细胞粘附研究中的潜力.

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Fibronectins Connect Cells with ECM01:25

Fibronectins Connect Cells with ECM

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Cell-matrix's Response to Mechanical Forces

In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...