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Updated: Jun 14, 2026

Nanomanipulation of Single RNA Molecules by Optical Tweezers
06:59

Nanomanipulation of Single RNA Molecules by Optical Tweezers

Published on: August 20, 2014

蛋白质-RNA相互作用的分子动力学和热力学:保存的芳香残留物的突变改变了U1A茎环2RNA复合体中的堆叠相互作用和结构适应

D M Blakaj1, K J McConnell, D L Beveridge

  • 1Chemistry Department, Molecular Biophysics Program, Wesleyan University, Middletown, Connecticut 06459, USA.

Journal of the American Chemical Society
|July 18, 2001
PubMed
概括

在U1A RNP域的Phe56向Ala的突变使U1 snRNA结合的稳定性降低了5.5 kcal/mol. 这是由于丢失的堆叠相互作用和改变的动态造成的,影响了保留和可变区域.

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