人类免疫缺陷病毒-1蛋白酶抑制剂的使用与异位性脂蛋白变化和内皮功能障碍有关
J H Stein1, M A Klein, J L Bellehumeur
1Department of Medicine, University of Wisconsin Medical School, Madison, Wisconsin, USA.
Circulation
|July 18, 2001
概括
人类免疫缺陷病毒蛋白酶抑制剂 (HIV PIs) 导致胆固醇的有害变化,并损害血管功能,增加动脉样硬化风险. 在服用这些药物的患者中,监测和治疗失脂症至关重要.
科学领域:
- 心血管医学 心血管医学
- 传染性疾病 传染性疾病
- 药理学 药理学 是一个学科.
背景情况:
- 人类免疫缺陷病毒蛋白酶抑制剂 (HIV PIs) 与多脂血症和肥胖等代谢问题有关.
- 艾滋病毒PIs对动脉样硬化血管疾病风险的影响尚不清楚.
- 这项研究调查了使用PI的HIV感染个体的脂蛋白异常和内皮功能.
研究的目的:
- 在PI治疗的HIV患者中表征脂蛋白异常.
- 评估这些变化对内皮功能障碍的病理生理意义.
主要方法:
- 对37名HIV-1感染成年人接受抗逆转录病毒治疗的横截面研究.
- 分为22个PI (组1) 和15个非PI (组2) 的PI (组2).
- 通过超声波测量脂质,脂蛋白 (酶,NMR) 和臂动脉流量介导血管扩张 (FMD).
主要成果:
- 第1组的总胆固醇和甘油三水平较高,IDL和VLDL水平较高.
- 第1组表现出受损的口炎 (2.6+/-4.6%),表明显著的内皮功能障碍.
- 第二组表现为正常的口炎 (8.1+/-6.7%).
- 脂蛋白水平 (chylomicron,VLDL,IDL,HDL) 预测了第一组的口病.
结论:
- 艾滋病毒PI与动脉质蛋白的变化和内皮功能障碍有关.
- 这些代谢和血管变化增加了对动脉样硬化的倾向.
- 建议对HIV PIs患者进行定期的血脂失调监测和管理.
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