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左心室结构和功能的多中心儿科心声谱测量的可靠性:前性P(2) C(2) HIV研究

S E Lipshultz¹, K A Easley, E J Orav

¹Division of Pediatric Cardiology, University of Rochester Medical Center and Children's Hospital at Strong, Rochester, NY, USA. steve_lipshultz@urmc.rochester.edu

|July 18, 2001

概括

对于左心室 (LV) 维度的儿科心声测量显示了当地和中央设施之间的高可靠性. 然而,LV壁厚度和分数缩短测量有显著差异,影响了它们的临床有效性.

科学领域:

儿童心脏病学儿童心脏病学
医疗成像医学成像
生物统计学生物统计学

背景情况:

评估儿科心声学测量的可靠性对于准确的患者护理至关重要.
对不同临床场所的测量标准化对于多中心研究至关重要.

研究的目的:

为了比较当地的儿科心声学测量的可靠性与在中央设施进行的测量.
评估左心室 (LV) 尺寸,壁厚度和分数缩短测量的一致性.

主要方法:

对10个临床场所的735名艾滋病毒感染母亲的孩子的心声回顾性分析.
本地测量与中央设施进行的重新测量的比较.
使用类内相关系数 (ICC) 和预测间隔 (PI) 的统计分析.

主要成果:

在LV维度测量中发现了高一致性 (ICC=0.97).
对后壁厚度 (ICC=0.65),分数缩短 (ICC=0.64) 和隔膜壁厚度 (ICC=0.50) 观察到较低的协议.
墙壁厚度的中央测量显示,与死亡率的相关性更强,这表明潜在的有效性更大.

结论:

左心室尺寸测量可靠地在本地和中央执行.
与中央评估相比,LV壁厚度和部分缩短的局部测量存在显著差异.
局部测量的变化可能会影响临床解释和结果.

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