相关实验视频
Updated: Jan 10, 2026
01:27
Pulmonary Embolism III: Nursing Management
Published on: June 19, 2025
320
缺乏血管内皮生长因子-B的小鼠表现出心房导电缺陷
1Ludwig Institute for Cancer Research, Stockholm Branch, Sweden.
Circulation
|July 18, 2001
概括
血管内皮生长因子-B (VEGF-B) 对于成人心脏功能至关重要,但对于心血管发育或成人血管生成至关重要. 缺乏VEGF-B的小鼠表现出心房导电异常.
科学领域:
- 心血管生物学 心血管生物学
- 分子生物学分子生物学
- 发展生物学 发展生物学
背景情况:
- 血管内皮生长因子 (VEGFs) 调节血管形成.
- VEGF-B的生理作用在很大程度上是未知的.
- VEGF-B在各种成年组织中表达,包括心脏.
研究的目的:
- 研究VEGF-B的生理功能.
- 确定VEGF-B在心血管发育和血管生成中的作用.
主要方法:
- 产生VEGF-B淘汰赛小鼠 (VEGF-B-/-) 的基因.
- 对VEGF-B-/-小鼠进行粗体器官检查.
- 电心电图 (ECG) 分析心脏功能.
- 对角膜血管生成的评估.
主要成果:
- VEGF-B-/-小鼠在高VEGF-B表达器官中没有明显异常.
- 成年VEGF-B-/-小鼠表现出心房传导异常 (延长PQ间隔).
- 由VEGF或FGF诱导的角膜血管生成在正常和VEGF-B-/-小鼠中是可比的.
结论:
- VEGF-B对于正常的成人心脏功能至关重要.
- 对于心血管系统的发展,不需要VEGF-B.
- 对于成年人的血管生成,VEGF-B是不可缺少的.
相关概念视频
Pulmonary Embolism III: Nursing Management
320
A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...
320
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
277
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
277
Pulmonary Embolism I: Introduction
464
Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
464
Venous Thrombosis III: Interprofessional Care
262
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
262
Pneumothorax-II
852
Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
Clinical Manifestations:
852
Chronic Obstructive Pulmonary Disease-V: Management
3.1K
Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
Smoking Cessation
3.1K