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Updated: May 11, 2026

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses
14:23

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses

Published on: August 31, 2014

在HIV感染中,稳定的CTL脱离突变的演变和传播

P J Goulder1, C Brander, Y Tang

  • 1Partners AIDS Research Center, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts 02114, USA. goulder@helix.mg.harvard.edu

Nature
|July 19, 2001
PubMed
概括

细胞毒性T淋巴细胞 (CTLs) 控制HIV-1,但在传播过程中可以出现逃生突变. 这些突变,特别是HLA-B27受限表位,影响病毒控制,并对艾滋病毒疫苗设计产生影响.

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