相关实验视频

Updated: Jun 24, 2026

RNAi Screening to Identify Postembryonic Phenotypes in C. elegans
09:40

RNAi Screening to Identify Postembryonic Phenotypes in C. elegans

Published on: February 13, 2012

与RNA干扰相关的基因和机制调节了控制C. elegans发育时间的小时间RNAs的表达

A Grishok1, A E Pasquinelli, D Conte

  • 1Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.

Cell
|July 20, 2001
PubMed
概括

RNA干扰 (RNAi) 和内源基因调控共享一个共同的处理途径. 关键的RNAi通路基因,包括Dicer同源dcr-1和rde-1同源alg-1和alg-2,对于小时RNA (stRNA) 成熟和功能在Caenorhabditis elegans中至关重要.

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Using RNA-mediated Interference Feeding Strategy to Screen for Genes Involved in Body Size Regulation in the Nematode C. elegans11:22

Using RNA-mediated Interference Feeding Strategy to Screen for Genes Involved in Body Size Regulation in the Nematode C. elegans

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Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster09:39

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster

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Types of RNA01:23

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Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the addition of a...