吸烟的中年男性的Apolipoprotein E4和冠心病:一个前性研究
S E Humphries1, P J Talmud, E Hawe
1Centre for Cardiovascular Genetics, Department of Medicine, Royal Free and University College London Medical School, Rayne Institute, WC1E 6JJ, London, UK. rmhaseh@ucl.ac.uk
Lancet (London, England)
|July 21, 2001
概括
吸烟在所有阿波利波蛋白E (APOE) 基因型中显著增加冠心病风险. 携带APOE epsilon4等位基因的男性在吸烟时面临着特别高的风险.
科学领域:
- 心血管遗传学 心血管遗传学
- 流行病学 流行病学
- 脂质代谢 脂质代谢是什么
背景情况:
- 脂蛋白E (apoE) 异型 (E2,E3,E4) 影响脂质水平和冠心病 (CHD) 风险.
- APOE epsilon4等位基因是已知的心脏病风险因素.
- 吸烟和APOE基因型对心脏病风险的相互作用需要进一步调查.
研究的目的:
- 检查APOE基因型如何改变吸烟与冠状动脉疾病风险之间的关联.
- 为了确定吸烟对心脏病的影响是否在具有不同APOE基因型的个体之间有所不同.
主要方法:
- 对3052名中年男性没有先前存在心脏病的潜在心血管监测 (北威克公园心脏研究II).
- 通过问卷和APOE基因定型使用PCR和限制酶消化来评估吸烟习惯.
- 监测心脏病终点,包括心肌梗塞,冠状动脉手术和静音心肌梗塞.
主要成果:
- 与从未吸烟者相比,吸烟者患心血管疾病的风险增加了1.94倍,而不依赖于其他风险因素.
- 在从未吸烟者中,在不同的APOE基因型中,心脏病风险相似.
- 与非吸烟者相比,携带APOE epsilon4等位基因的吸烟者显示心脏病风险显著增加 (2.79倍),这表明基因与环境的相互作用很强 (p=0.007).
结论:
- 在所有APOE基因型中,吸烟是冠状动脉心脏病的重要危险因素.
- 具有APOE epsilon4等位基因的个体在吸烟时,心血管疾病风险增加不成比例.
- 这些发现突显了心血管疾病中遗传倾向 (APOE基因型) 和生活方式因素 (吸烟) 之间的关键相互作用.
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