慢性心力衰竭患者的肌肉交感神经活动的呼吸调节
1Second Department of Internal Medicine, The First Department of Physiology, Toyama Medical and Pharmaceutical University, Toyama, Japan.
Circulation
|July 27, 2001
概括
患有心力衰竭的患者表现出减少的潮体积,导致对交感神经活动的抑制较少. 这表明受损的肺膨胀反射有助于慢性心力衰竭中的同情激发.
科学领域:
- 心脏病学 心脏病学
- 呼吸系统生理学 呼吸系统生理学
- 神经科学是一个神经科学.
背景情况:
- 交感兴奋和呼吸系统不稳定与慢性心力衰竭的恶化有关.
- 了解同情活动的呼吸调节对于心力衰竭患者至关重要.
研究的目的:
- 研究心力衰竭中呼吸模式和交感神经活动之间的动态关系.
- 为了确定通风体积如何影响肌肉交感神经活动 (MSNA) 在单次呼吸.
主要方法:
- 在23名患者中记录了MSNA,血压和呼吸流量,左心室喷射率≤45%.
- 分析了MSNA的呼吸内变化,在一些患者中确定了"神经沉默" (抑制).
- 评估了潮体积和MSNA抑制之间的关系,在受控呼吸期间使用指数函数拟合.
主要成果:
- 在23名患者中,在11名患者中观察到呼吸内MSNA抑制.
- 没有MSNA抑制的患者的潮体积显著减少,呼吸速率更高.
- 为了在缺乏神经沉默的患者中实现MSNA抑制,需要更大的潮体积,这表明有减弱的交感抑制性肺膨胀反射.
结论:
- 慢性心力衰竭中的交刺激与静止潮体积的减少有关.
- 肺膨胀反射的减弱的同情抑制作用有助于心力衰竭中的同情过度活跃.
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