Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Becotatug Vedotin for Recurrent/Metastatic Nasopharyngeal Carcinoma (Magic-M001): A Multicenter, Randomized Trial.

Annals of oncology : official journal of the European Society for Medical Oncology·2026
Same author

[Intestinal involvement in systemic lupus erythematosus: a clinicopathological analysis of three cases].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2026
Same author

[Quantitative analysis of policy texts on occupational health technical service institutions in China based on policy tools].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases·2026
Same author

[Clinical efficacy of multidisciplinary team collaboration in the treatment of deep sternal wound infection].

Zhonghua shao shang yu chuang mian xiu fu za zhi·2025
Same author

Measurement of the Positive Muon Anomalous Magnetic Moment to 127 ppb.

Physical review letters·2025
Same author

[Clinical efficacy of composite transplantation of fascia lata-anterolateral thigh flap in repairing complex defects after radical tumor resection in maxillofacial region].

Zhonghua shao shang yu chuang mian xiu fu za zhi·2025

相关实验视频

Updated: Jul 1, 2026

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
06:43

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

Published on: December 8, 2013

加速动脉样硬化,大动脉动脉瘤形成和缺血性心脏病在阿波利波蛋白E/内皮氧化合成酶双敲击小鼠中的加速动脉样硬化,大动脉动脉瘤形成和缺血性心脏病.

P J Kuhlencordt1, R Gyurko, F Han

  • 1Cardiovascular Research Center, Cardiology Division, Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA.

Circulation
|July 27, 2001
PubMed
概括

内皮氧化合成酶 (eNOS) 缺乏会显著加快动脉样硬化,并导致西方饮食小鼠的冠心病. 这导致心力衰竭和大动脉并发症,不仅仅是由于高血压.

更多相关视频

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice
07:36

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice

Published on: September 26, 2018

Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions
06:08

Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions

Published on: March 8, 2019

相关实验视频

Last Updated: Jul 1, 2026

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
06:43

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

Published on: December 8, 2013

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice
07:36

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice

Published on: September 26, 2018

Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions
06:08

Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions

Published on: March 8, 2019

科学领域:

  • 心血管研究研究心血管研究
  • 动脉样硬化病原体的产生
  • 鼠模型的模型

背景情况:

  • 内皮氧化合成酶 (eNOS) 在血管健康中起作用.
  • 动脉样硬化是一种复杂的心血管疾病.
  • 了解影响动脉样硬化的遗传因素至关重要.

研究的目的:

  • 研究eNOS缺乏对动脉样硬化发展的影响.
  • 为了比较双淘汰赛 (apoE/eNOS-DKO) 和对照 (apoE-KO) 小鼠中的病变形成.
  • 为了确定与eNOS缺乏相关的心血管并发症.

主要方法:

  • 在apoE/eNOS-DKO小鼠和apoE-KO小鼠中病变发展的比较.
  • 在16周的时间里,用西方式的饮食养动物.
  • 评估动脉样硬化,冠状动脉样硬化,纤维化,心脏功能和大动脉完整性.

主要成果:

  • 与apoE-KO对照组相比,apoE/eNOS-DKO小鼠的病变区域显著增加 (93.6%的雄性,59.2%的雌性).
  • DKO动物出现了外周冠状动脉硬化,纤维化和心脏功能障碍 (增加LV壁厚度,减少分数缩短).
  • 雄性DKO小鼠表现出自发的大动脉动脉瘤和剖析;在apoE-KO小鼠中没有观察到这些并发症.

结论:

  • 在小鼠模型中,eNOS缺乏会加剧动脉样硬化,并诱导冠心病.
  • 这项研究提出了第一个与心肌缺血症,心脏病发作和心力衰竭相关的远端冠状动脉硬化病的小鼠模型.
  • 在DKO小鼠中,心血管并发症,包括缩和功能障碍,不仅仅归因于血压升高.