用超声波破坏对比微泡:对心肌功能,冠状动脉 perfusion 压力和微血管完整性的影响
1Division of Cardiology, Université Catholique de Louvain, School of Medicine, Brussels, Belgium.
Circulation
|July 27, 2001
概括
超声波对比剂与超声波能量相结合,可以在隔离的子心脏中引起暂时的心脏功能障碍和微血管破裂. 这种影响取决于机械指数 (MI),可能导致心肌损伤.
科学领域:
- 心血管研究研究心血管研究
- 生物医学工程 生物医学工程
- 超声波技术 超声波技术 超声波技术
背景情况:
- 最近的研究表明,超声波诱导的微气泡破坏可以破裂微血管.
- 对心脏组织的功能和形态影响需要进一步研究.
研究的目的:
- 为了评估超声波和对比剂同时暴露对隔离的子心脏的影响.
- 确定声能水平与心脏反应之间的关系.
主要方法:
- 隔离的子心脏被注入了对比剂,并暴露在不同声能水平 (1.8 MHz/3.6 MHz,1 Hz触发模式) 的超声波中.
- 测量了左心室发育压力,冠状动脉 perfusion 压力和心肌乳酸释放.
- 通过宏观和显微镜检查心脏,以确定固定后的结构损伤.
主要成果:
- 同时的对比度和超声波暴露导致左心室发育压力的短暂,机械指数 (MI) 取决于下降 (83%的基线在MI 1.6).
- 观察到冠状动脉输液压的短暂MI-依赖的增加 (120%的基线在MI 1.6) 和心肌乳酸释放的升高.
- 显微镜检查显示了毛细血管破裂 (3.6%在MI 1.6),红细胞扩散和内皮细胞损伤,在较高的MI中发现了宏观出血.
结论:
- 结合的超声波和对比剂以剂量依赖的方式诱导暂时的心脏功能障碍和微血管损伤.
- 观察到的效应包括左心室功能减弱,冠状动脉 perfusion 压力增加,乳酸产量增加和毛细血管损伤.
- 这些发现突出了机械指数 (MI) 作为超声波对比成像安全评估中的关键参数.
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