在子模型中,用 (186) 重新标记的支架预防缩
G Tepe1, L M Dinkelborg, U Brehme
1Department of Diagnostic Radiology, Institute of Pathology, University of Tübingen, Germany. gunnar.tepe@med.uni-tuebingen.de
Circulation
|July 27, 2001
概括
标有-186的支架有效地减少了子血管造形术后的新极端增殖. 这些放射性支架表现出剂量依赖的效果,减少组织生长而不会引起晚期血栓形成.
科学领域:
- 心血管研究研究心血管研究
- 干预心脏病学 干预心脏病学
- 放射性药物疗法是一种放射性药物疗法.
背景情况:
- 内β辐射在降低血管造形术后的新极度增生症方面显示出有前途.
- 实验模型表明局部辐射治疗的潜在好处.
研究的目的:
- 评估使用标有-186 ((186) Re) 的支架的技术可行性.
- 评估 (186) 重新标记的支架对新极端增殖的生物学影响.
主要方法:
- 帕尔马兹支架植入了34只新西兰白在胆固醇饮食中的下主动脉.
- 动物被用对照支架或 (186) 重新标记的支架治疗,剂量不同 (2.6到25.3 MBq).
- 在植入后7周评估了neointima形成.
主要成果:
- 在所有子中,支架植入在技术上是成功的,没有观察到血栓封闭.
- 观察到与剂量相关的neointima形成的减少,在较高剂量 (16.0和25.3MBq) 时完全抑制.
- 辐射暴露导致了延迟的再内皮细胞化,但并没有诱导在支架边缘的新内皮细胞形成.
结论:
- 标有-186 ((186) Re) 标签的支架在技术上是可行的,并且可以有效地以剂量依赖的方式减少新密的形成.
- (186) 在7周的观察期内,静脉支架没有诱导晚期血栓形成或在静脉支架边缘的新极端增生.
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