尼比沃洛可逆转精性高血压中的内皮功能障碍:一项随机,双盲,交叉研究
N Tzemos1, P O Lim, T M MacDonald
1Hypertension Research Centre, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee, United Kingdom. n.tzemos@dundee.ac.uk
Circulation
|August 2, 2001
概括
尼比沃洛 (Nebivolol) 是一种血管扩张β-阻断剂,通过增强氧化的释放来改善高血压患者的内皮功能. 与阿提诺洛尔不同,尼比沃洛尔提供了超出血压控制的额外血管保护.
科学领域:
- 心血管药理学心血管药理学
- 内皮功能研究研究 内皮功能研究
- 高血压治疗药物 高血压治疗药物
背景情况:
- 血管内皮功能障碍是动脉样硬化的预测因素.
- 在降低血压的同时逆转内皮功能障碍可能会改善高血压的预后.
- 尼比沃洛 (Nebivolol) 是一种血管扩张β-阻断剂,被假设可以改善内皮功能障碍.
研究的目的:
- 为了比较nebivolol和atenolol对高血压患者内皮功能的影响.
- 研究nebivolol在改善内皮功能障碍方面的潜力.
主要方法:
- 在12名高血压患者中进行了双盲交叉研究,比较了nebivolol/bendroflumethiazide和atenolol/bendroflumethiazide.
- 前臂静脉闭塞整体图用于评估通过乙胆和N(G) -单甲基-L-氨酸 (L-NMMA) 输液的内皮依赖的氧化释放.
- 使用酸普鲁塞德评估的内皮独立途径.
主要成果:
- 尼比沃洛/本德罗夫梅西亚齐德和阿提诺洛/本德罗夫梅西亚齐德都同样降低了血压.
- 尼比沃洛/本德罗弗卢梅西亚齐德显著增加了对乙胆的血管扩张反应 (435+/-27%,P<0.001).
- 尼比沃洛/本德罗夫米亚齐德改善了内皮依赖L-NMMA的血管收缩 (-54+/-5%,P<0.001),而阿诺洛/本德罗夫米亚齐德没有.
- 两组之间对酸的反应没有显著差异.
结论:
- 尼比沃洛/本德罗弗卢梅西亚齐德增强了刺激和基底内皮氧化释放.
- 尽管有类似的血压降低,但阿提诺洛尔/本德罗夫甲酸并没有影响氧化的生物活性.
- 与阿提诺洛尔相比,内比沃洛尔在高血压管理中可以提供更好的血管保护.
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