鼻腔节律激活和回入心室性心跳动脉之间的关系
E J Ciaccio1, A C Tosti, M M Scheinman
1Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. ciaccio@columbia.edu
Circulation
|August 2, 2001
概括
鼻腔节律激活映射可以预测回入腹腔动心跳动的诱导性,并精确地定位关键脉. 这种方法有助于指导复杂心律失常的废除策略.
科学领域:
- 心血管电生理学 心血管电生理学
- 心脏节律失常研究 心脏节律失常研究
- 翻译性动物模型
背景情况:
- 狗心中的复发性心室动脉冲动 (VT) 脉冲形成往往与鼻腔节律激活模式保持一致.
- 量化这种关系可以预测静脉瘤诱导性和静脉位位置.
研究的目的:
- 测试假设,鼻节律激活参数可以预测再入诱导性和地峡位置.
- 在狗模型中评估这种预测方法的准确性.
主要方法:
- 采用了心上边界区域重新进入的现场犬类模型.
- 生成了鼻节律激活地图,并沿8个射线计算了回归系数.
- 确定了主要轴,并使用它的斜率来预测重新进入.
- 根据鼻节律电图持续时间差异估计的脉位置和形状.
主要成果:
- 主轴斜率在54个实验中的48个实验中正确预测了重新进入的诱导性.
- 据估计,地峡的位置和形状与实际的地峡有部分重叠 (71.3%的长途运行,43.6%的短途运行).
- 一个线性剥离损伤跨越估计的峡谷将覆盖78.2%的实际峡谷宽度平均.
结论:
- 鼻腔节律激活参数对于预测重新进入诱导性是有价值的.
- 这些参数提供了重要的信息,用于估计重新进入的峡谷的位置和形状.
- 这种方法对引导静脉治疗中的导管切除程序有潜在的影响.
相关概念视频
The Cardiac Cycle
The heart beats rhythmically in a sequence called the cardiac cycle—a rapid coordination of contraction (systole) and relaxation (diastole).
The Process
Electrical signals—sent from the sinoatrial (SA) node in the right atrial wall to the atrioventricular (AV) node between the right atrium and right ventricle—cause both atria to simultaneously contract. When the signal reaches the AV node, it pauses for approximately a tenth of a second, allowing the atria to contract and empty blood into the...
The Process
Electrical signals—sent from the sinoatrial (SA) node in the right atrial wall to the atrioventricular (AV) node between the right atrium and right ventricle—cause both atria to simultaneously contract. When the signal reaches the AV node, it pauses for approximately a tenth of a second, allowing the atria to contract and empty blood into the...
Electrophysiology of Normal Cardiac Rhythm
The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase of...
Mechanism of Cardiac Arrhythmias
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
Conduction System of the Heart
Autorhythmicity is a term that refers to the heart's inherent ability to generate electrical signals and instigate muscle contractions. This self-regulating conduction system within the heart consists of two key components: the pacemaker cells and specialized conducting cells.
The pacemaker cells are located in two primary nodes: the sinoatrial (SA) node and the atrioventricular (AV) node. The SA node pacemaker cells can autonomously depolarize, triggering an action potential that leads to the...
The pacemaker cells are located in two primary nodes: the sinoatrial (SA) node and the atrioventricular (AV) node. The SA node pacemaker cells can autonomously depolarize, triggering an action potential that leads to the...
Regulation of Heart Rates
The regulation of heart rate is a complex process controlled by the autonomic nervous system (ANS), hormonal influences, and intrinsic cardiac mechanisms. The ANS has two main components: the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS).
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
Conduction System of the Heart
The cardiac conduction system produces and transmits electrical impulses that prompt myocardial contraction, ensuring efficient heart function. This intricate system ensures that the heart beats in a coordinated and efficient manner, beginning with the atria and then the ventricles. The conduction system optimizes cardiac output by maintaining this precise sequence, which is crucial for adequate blood circulation.
This system relies on the unique properties of nodal and Purkinje cells:...
This system relies on the unique properties of nodal and Purkinje cells:...


