周围血液或骨髓移植后的怀孕结果:回顾性调查
N Salooja1, R M Szydlo, G Socie
1Department of Haematology, Imperial College of Science and Medicine, Hammersmith Hospital, London, UK.
Lancet (London, England)
|August 11, 2001
概括
在干细胞移植 (SCT) 后,可以保持或恢复生育能力. 虽然受孕率很低,但大多数怀孕都会导致活产,尽管所有移植受体需要高风险监测.
科学领域:
- 血液学 血液学 血液学
- 生殖医学 生殖医学
- 在瘤学瘤学.
背景情况:
- 干细胞移植 (SCT) 可能导致某些患者不孕.
- 在接受SCT的个体中,生育能力的结果各不相同.
研究的目的:
- 评估在接受了自主或异性SCT的患者的受孕和怀孕结果.
- 评估SCT后的生育恢复和怀孕成功率.
主要方法:
- 一项调查分发给欧洲血液和骨髓移植中心的229个中心.
- 收集的数据包括原始疾病,移植细节和男性和女性患者的受孕结果.
主要成果:
- 232名 (0.6%) 患者在SCT后受孕,其粗略年出生率为每1000名幸存者1.7.
- 在113名患者和伴侣中报告了312例怀孕,导致271例活产.
- 与普通人群相比,所有移植受体的剖腹产,早产和低出生体重后代的发生率更高.
结论:
- 在SCT之后的怀孕通常具有成功的结果.
- 整体移植接受者,特别是那些全身辐射患者,面临高风险怀孕,需要谨慎管理.
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