在正常和过度活跃的膀功能中,外围自主模块和肌肌的模型.
M J Drake1, I W Mills, J I Gillespie
1Tyne Micturition Research Group, School of Surgical Sciences, Medical School, University of Newcastle upon Tyne NE2 4HH, UK. marcus.drake@doctors.org.uk
Lancet (London, England)
|August 15, 2001
概括
周围神经系统的活动可能比以前认为的在膀控制中发挥更大的作用. 这项研究提出,膀过度活跃源于模块化鱼肌肉结构内外围自主活动的不平衡.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 神经科学是一个神经科学.
- 身体生理学 身体生理学
背景情况:
- 正常的膀功能主要归因于中枢神经系统 (CNS) 的控制.
- 存在一种潜在的,但被低估的,对膀控制的外围贡献.
研究的目的:
- 提出一种新的膀控制模型,涉及周围神经系统机制.
- 调查外围自主活动在破坏者过度活动中的作用.
主要方法:
- 模块化detrusor肌肉安排的概念化.
- 假设一个外周肌肉控制这些模块.
- 提出一种基于外周活动的新机制来治疗虫虫过度活跃.
主要成果:
- 驱动器肌肉可以组织成功能模块.
- 一个外周肌,包括和间歇细胞,可以调节这些模块.
- 破坏者过度活跃可能来自于这些外围模块内的激发抑制平衡的改变.
结论:
- 周围神经系统显著影响膀功能.
- 抑郁体过度活跃可能与外围自主活动的失调有关.
- 针对外围结构为膀过活性的治疗提供了潜在的新疗法策略.
相关概念视频
Extracellular Matrix
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
Gross Anatomy of Skeletal Muscles
The connective tissues play a significant role in arranging the muscle fibers into a hierarchical structure that forms a complete muscle. Consider a muscle like the bicep brachii, commonly called the bicep. This muscle comprises thousands of muscle fibers enclosed by a protective layer of connective tissue called the endomysium. The endomysium is primarily composed of reticular fibers, a type of thin collagen fiber. It allows the exchange of nutrients and waste products at the fiber level,...
Axial and Appendicular Muscles
Skeletal muscles, the key players in our body's movement, can be classified into two groups based on their location and function: axial muscles and appendicular muscles. These classifications reflect the primary roles the muscles play in the body's structure and movement.
Axial Muscles
Axial muscles, situated along the body's midline, are intricately connected to the axial skeleton, which includes the skull, spine, ribs, and sternum. These muscles facilitate facial expressions and play a...
Axial Muscles
Axial muscles, situated along the body's midline, are intricately connected to the axial skeleton, which includes the skull, spine, ribs, and sternum. These muscles facilitate facial expressions and play a...
Muscles for Facial Expressions
The craniofacial muscles are a collection of approximately 20 thin skeletal muscles situated beneath the skin of the face and scalp. These muscles, primarily responsible for the vast array of human facial expressions, originate from the bones or fibrous structures of the skull and extend outwards to connect with the skin. While most skeletal muscles in the body are enveloped in thick fascia, facial muscles generally have a more delicate fascial covering, with the buccinator muscle being a...
Muscles that Move the Arm
Nine muscles are involved in arm movements. Two of these, the pectoralis major and latissimus dorsi, originate from the axial skeleton and are called axial muscles. The other seven originate from the scapula and are called the scapular muscles.
The pectoralis major has two origins. Its clavicular head originates on the medial half of the clavicle. In contrast, the sternocostal head originates on the costal cartilages of ribs 1-6, the sternum, and the aponeurosis of the external oblique of the...
The pectoralis major has two origins. Its clavicular head originates on the medial half of the clavicle. In contrast, the sternocostal head originates on the costal cartilages of ribs 1-6, the sternum, and the aponeurosis of the external oblique of the...
Muscles that Move the Forearm
The muscles that move the forearms can be divided into four groups: forearm flexors, forearm extensors, forearm pronators, and forearm supinators. The flexors and extensors act on the elbow joint, while the pronators and supinators act on the radioulnar joints.
Forearm Flexors
The biceps brachii, brachialis, and brachioradialis are forearm flexors. The biceps brachii is made up of two heads. Its long head originates at the supraglenoid tubercle of the scapula, whereas that of the short head is...
Forearm Flexors
The biceps brachii, brachialis, and brachioradialis are forearm flexors. The biceps brachii is made up of two heads. Its long head originates at the supraglenoid tubercle of the scapula, whereas that of the short head is...


