循环中的非化脂肪酸水平作为人口突然死亡的预测风险因素
X Jouven1, M A Charles, M Desnos
1Service de Cardiologie, Université Paris-5, Faculté Necker-enfants malades, Hôpital Européen Georges Pompidou, Paris, France. xavier.jouven@hop.egp.ap-hop-paris.fr
Circulation
|August 15, 2001
概括
高水平的非化脂肪酸 (NEFA) 是中年男性突然心脏病死亡的独立危险因素. 这一发现表明,在有风险的个体中,有潜在的初级预防策略.
科学领域:
- 心脏病学 心脏病学
- 代谢综合征是代谢综合征的一种.
- 流行病学 流行病学
背景情况:
- 过高的非化脂肪酸 (NEFA) 与缺血条件下的心律失常有关.
- 高NEFA与非缺血患者的早发性心室综合体有关.
- 之前没有研究过NEFA在无症状个体突然死亡中的作用.
研究的目的:
- 评估循环NEFA与无症状男性突然死亡之间的关联.
- 确定NEFA是否是突然死亡的独立风险因素.
主要方法:
- 对5250名无症状男性进行的长期队列研究 (巴黎前性研究I).
- 测量空腹血NEFA度的方法.
- 分析调整了包括BMI,血压和胆固醇在内的混因素.
主要成果:
- 循环NEFA度是突然死亡的独立风险因素 (RR,1.70).
- 没有发现NEFA是致命心肌梗塞的独立风险因素.
- 与突然死亡相关的因素包括BMI,血压,吸烟,父母病史,胆固醇和NEFA.
结论:
- 循环NEFA度是中年男性突然死亡的独立预测因素.
- 初级预防策略对于高NEFA水平的个体可能是有益的.
- 进一步研究NEFA在心血管事件中的作用是有必要的.
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