相关概念视频
01:34Directing Proteins to the Rough Endoplasmic Reticulum
The organelle-specific signaling sequences direct proteins synthesized in the cytosol to their final destination like ER, mitochondria, peroxisomes, etc. Some of the proteins directed to ER are then trafficked via vesicles to other organelles within the cell or the extracellular environment through the Golgi complex. For example, the rough ER synthesizes soluble proteins for transportation to the lysosomes or secretion out of the cell. It can also synthesize transmembrane proteins that can...
01:26Protein Modifications in the RER
Modification of secretory and transmembrane proteins entering the rough ER begins in the ER lumen. These modifications aid in protein folding and stabilize the acquired tertiary structure. Protein modifications in the rough ER co-occur at different stages of protein folding.
Broadly, these modifications can be categorized into four main categories — glycosylation, formation of disulfide bonds, assembly of protein subunits, and specific proteolytic cleavages like removal of signal sequences.
Broadly, these modifications can be categorized into four main categories — glycosylation, formation of disulfide bonds, assembly of protein subunits, and specific proteolytic cleavages like removal of signal sequences.
01:29GPI Anchoring of Proteins in the ER Membrane
GPI-anchoring is a post-translational, reversible protein modification that is ubiquitous in eukaryotes. Such proteins are primarily present on the exoplasmic leaflet of the plasma membrane.
GPI-anchor structure
A sequence of 11 enzymatic reactions results in the synthesis of the complete GPI anchor consisting of a hydrophobic and a hydrophilic portion. The hydrophobic portion comprises phosphatidylinositol, while the hydrophilic part comprises polar groups like phosphoethanolamine,...
GPI-anchor structure
A sequence of 11 enzymatic reactions results in the synthesis of the complete GPI anchor consisting of a hydrophobic and a hydrophilic portion. The hydrophobic portion comprises phosphatidylinositol, while the hydrophilic part comprises polar groups like phosphoethanolamine,...
01:27Transducer Mechanism: Enzyme-Linked Receptors
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Major types that are helpful drug targets include:
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p400复合体是一个重要的E1A转换目标.
Cell
|August 18, 2001
概括
研究人员发现了一种新的E1A结合蛋白复合体,对E1A介导的转化至关重要. 核心成分p400及其相关蛋白质对于这一过程至关重要,突出显示它们在细胞转化中的作用.
科学领域:
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
- 在瘤学瘤学.
背景情况:
- E1A蛋白是一种关键的病毒蛋白,已知可诱导细胞转化.
- 了解E1A介导转化背后的分子机制对于癌症研究至关重要.
研究的目的:
- 识别和描述与E1A相互作用的新型蛋白质复合体.
- 阐明这些复合体在E1A介导的细胞转化中的作用.
主要方法:
- 同免疫沉测试以确定E1A结合伙伴.
- 鉴定的蛋白质复合体的生物化学表征.
- 使用E1A突变体和蛋白质碎片来评估转化活动的功能测试.
主要成果:
- 鉴定了一种新型E1A结合蛋白复合体,其中包含p400作为核心成分.
- 证明E1A-p400复合体对于E1A介导的转化是必不可少的.
- 证据表明E1A和c-myc可以调节p400复合物的子单元组成.
结论:
- 在E1A转化过程中,E1A-p400复合体起着至关重要的作用.
