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在发芽的酵母中对动态 - 微管附着的分子分析

X He1, D R Rines, C W Espelin

  • 1Massachusetts Institute of Technology, Department of Biology, Cambridge, MA 02139, USA.

Cell
|August 21, 2001
PubMed
概括

研究人员在酵母中发现了十种kinetochore蛋白,包括动物微管结合物的同类蛋白. 这些蛋白质对于染色体分离至关重要,通过确保姐妹基因和细胞分裂期间适当的运动之间的紧张.

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Attachment of Sister Chromatids02:57

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As cells progress into mitosis, the nuclear envelope breaks down, and the condensed chromosomes are exposed to the array of bipolar microtubules of the mitotic spindle. The kinetochore, a large, disc-shaped protein complex, is present at the centromere region of the sister chromatids and acts as a binding site for the microtubules.  Usually, the plus-end of a single microtubule is embedded within the kinetochore. However, some kinetochores first establish lateral contact with the side-wall...
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