来自糖氨基酸的循环同类聚合物:合成,构造分析和意义
E Locardi1, M Stöckle, S Gruner
1Institut für Organische Chemie und Biochemie, Technische Universität München, Lichtenbergstrasse 4, D-85747 Garching, Germany.
Journal of the American Chemical Society
|August 23, 2001
概括
新的糖氨基酸 (SAA) 被合成成周期性寡合体. 这些新型循环SAA显示出作为宿主分子的潜力,与宾客分子 (如酸) 形成包含综合体.
科学领域:
- 碳水化合物化学 碳水化合物化学
- 超分子化学 超分子化学
- 有机合成 有机合成
背景情况:
- 糖氨基酸 (SAA) 是一种具有碳水化合物支架上的氨基和碳酸基组的新型构建块.
- 以前的循环寡合体合成主要涉及非SAA单元.
研究的目的:
- 为了合成糖氨基酸的线性和循环同类聚合物.
- 研究这些新型循环SAA的构造性质和宿主-客体复合能力.
主要方法:
- 固体和溶液相合过程用于寡合化和循环化.
- 合成含有两,三,四和六个葡萄糖氨酸甲基胺 () 单位的同类聚合物.
- 核磁共振光谱 (化学转移,T(1) 放松,扩散系数) 用于研究宿主-客人复杂化.
主要成果:
- 高产量和短的合时间在的寡合化和循环化中得到了实现.
- 仅由SAA组成的循环寡合体的合成首次实现.
- 循环六合体对酸和p-nitrophenol的复合通过光谱和扩散研究得到证实.
结论:
- 成功合成了新的循环糖氨基酸寡合物.
- 这些循环SAA表现出类似于循环德克斯的宿主-客人复杂化行为.
- 这些发现为开发基于碳水化合物支架的新超分子结构开辟了道路.
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