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Updated: Jul 13, 2026

In utero Electroporation followed by Primary Neuronal Culture for Studying Gene Function in Subset of Cortical Neurons
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Published on: October 9, 2010

转基因小鼠表达突变和APP的增强的神经纤维细胞退化

J Lewis1, D W Dickson, W L Lin

  • 1Birdsall Building, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA.

Science (New York, N.Y.)
|August 25, 2001
PubMed
概括

研究人员交叉了tau和β-粉样蛋白前体蛋白 (APP) 的小鼠. 双重突变者表现出增强的神经纤维状结,表明APP或Abeta影响结形成,支持阿尔茨海默氏症病理学假设.

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