膜大动脉狭窄患者的亚膜梯度:患病率,大小和生理重要性
1Division of Cardiology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. wlaskey@ medicine.umaryland.edu
Circulation
|August 29, 2001
概括
亚膜梯度在大动脉狭窄中很常见,平均近一半的总梯度. 运动显著增加了这些梯度,反过来影响了心脏输出,亚膜梯度预测了反应.
科学领域:
- 心脏病学 心脏病学
- 心血管生理学心血管生理学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 大动脉狭窄的亚膜梯度是已知的,但不太了解.
- 它们在运动期间的动态行为仍然没有特征.
研究的目的:
- 在大动脉狭窄中表征亚膜梯度.
- 为了研究它们对卧卧运动的反应.
- 为了确定梯度和心脏输出响应之间的关系.
主要方法:
- 用于压力和速度测量的导管尖度计.
- 休息时和卧卧运动时进行的测量.
- 该研究包括27名患有膜大动脉狭窄症的患者.
主要成果:
- 亚膜梯度平均占总静止梯度的48%.
- 总和亚膜梯度随着运动显著增加.
- 运动下膜梯度,但不是总量,预测心脏输出响应.
结论:
- 下压力梯度在严重的大动脉狭窄时普遍存在.
- 这些梯度约占整个跨膜梯度的一半.
- 增加的运动心脏输出与亚膜梯度大小相反.
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