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相关概念视频

Determination01:51

Determination

21.3K
During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
21.3K

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相关实验视频

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Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps
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Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps

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德洛索菲拉神经细胞序列表达转录因子,这些因子确定其神经元后代的时间同一性.

T Isshiki1, B Pearson, S Holbrook

  • 1Institute of Neuroscience/Institute of Molecular Biology, Howard Hughes Medical Institute, 1254 University of Oregon, Eugene, OR 97403, USA.

Cell
|August 30, 2001
PubMed
概括

草神经母细胞使用序列转录因子来指定细胞命运. 驼背和克鲁佩尔是神经发育中早期出生细胞身份的关键.

科学领域:

  • 发育生物学是发展生物学.
  • 神经科学是一个神经科学.
  • 遗传学 是一个遗传学.

背景情况:

  • 神经前体连续产生各种各样的细胞类型.
  • 控制细胞命运时间的线索在很大程度上是未知的.

研究的目的:

  • 研究Drosophila神经细胞中控制细胞命运规范的分子机制.
  • 确定参与调节细胞类型生成顺序的转录因子.

主要方法:

  • 在Drosophila神经细胞中对转录因子表达模式的分析.
  • 使用基因操纵来评估转录因子的必要性和充分性的功能性研究.

主要成果:

  • 德洛索菲拉神经母细胞连续表达头,克鲁佩尔,Pdm和卡斯托尔.
  • 驼背是第一个出生细胞命运的必要和足够的.
  • 克鲁佩尔对于第二个出生细胞命运来说是必不可少的,足够的,独立于细胞类型.

结论:

  • 驼背和克鲁佩尔在神经细胞系中建立早期时间身份方面发挥着关键作用.
  • 这种转录因子级联为理解神经发育中的时间模式提供了一个框架.

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