鉴定一种对内分泌腺内皮细胞有选择性的血管性菌原体
J LeCouter1, J Kowalski, J Foster
1Department of Molecular Oncology, Genentech Inc., South San Francisco, CA 94080, USA.
Nature
|August 31, 2001
概括
一个新发现的生长因子,内分泌腺衍生血管内皮生长因子 (EG-VEGF),选择性地促进内分泌腺内皮细胞的生长. 这一发现揭示了血管内皮生长的组织特异性调节.
科学领域:
- 内分泌学 在内分泌学.
- 血管生物学 血管生物学
- 细胞生物学 细胞生物学
背景情况:
- 内皮细胞的辅激素通常会广泛刺激血管内皮细胞.
- 需要了解组织特异性血管生长调节.
研究的目的:
- 识别和描述一种具有选择性内皮细胞活性的新生长因子.
- 调查这种因素在内分泌腺血管化中的作用.
主要方法:
- 隔离和表征来自内分泌腺的血管内皮生长因子 (EG-VEGF).
- 对内皮细胞增殖,迁移和化进行检测.
- 在卵巢,角膜和骨肌中的血管生成体内研究.
- 对EG-VEGF和VEGF表达模式的分析.
主要成果:
- 在内分泌腺毛细体内皮细胞中,EG-VEGF选择性诱导了增殖,迁移和化.
- EG-VEGF表达是由缺氧诱导的,与VEGF共享一个HIF-1结合点.
- EG-VEGF促进了卵巢血管生成和囊的形成,但不是在角膜或骨肌肉中.
- EG-VEGF mRNA表达仅限于类固醇性腺体,卵巢,丸,上腺和胎盘.
结论:
- EG-VEGF是一种新型的,针对内分泌腺血管内皮的组织特异性菌原体.
- 在血管生成中,EG-VEGF和VEGF可能会协调起作用.
- 这一发现突出了调节组织特异性血管发育的新一类特定线粒原体.
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