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B Mollereau¹, M Dominguez, R Webel

¹Department of Biology, New York University, New York, USA.

|August 31, 2001

概括

果中光受体细胞的命运是一个两步的过程. 分裂基因复合体对于幼发育期间的终端分化至关重要,在幼中初始神经元承诺后确定最终细胞特性.

科学领域:

发育生物学是发展生物学.
神经科学是一个神经科学.
遗传学是一个遗传学.

背景情况:

大虫中摄影受体细胞的形成是神经元分化的一个模型.
人们认为细胞命运在幼虫阶段被不可逆转地设定.
最终的分化,包括拉布多形态发生和素表达,发生在幼发育过程中.

研究的目的:

为了研究 (sal) 基因复合体在光感受器分化中的作用.
要确定光受体细胞命运是在单个阶段还是多个阶段建立的.

主要方法:

在Drosophila.spalt (sal) 基因复合体功能分析.
在光受体细胞中检查拉布多体形态和素基因表达.
在视叶中追踪轴突突出.

主要成果:

斯帕尔特复合体在化晚期需要用于光受体分化.
缺少合体复合体会改变内光受体细胞 (R7,R8) 中的体形态和素表达 (R7,R8).
缺少裂的内部光受体细胞保留了幼虫阶段的轴突投射目标.

结论:

光受体的分化是一个两步的过程:幼虫承诺和轴突向,其次是幼末端分化.
分裂基因复合体调节终端分化,建立最终的细胞特性.
在光受体发育过程中,轴突投射和最终细胞命运是独立调节的.

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