了解固体/固体有机反应
G Rothenberg1, A P Downie, C L Raston
1York Green Chemistry Group, Chemistry Department, University of York, Heslington, York YO10 5DD, UK.
Journal of the American Chemical Society
|September 6, 2001
概括
大多数固相有机反应都涉及液相,由研磨固体反应物形成. 这种eutectic混合物形成解释了反应动力学,并挑战了真正的固体相反应的概念.
科学领域:
- 有机化学 有机化学
- 材料科学 材料科学 材料科学
- 物理化学 物理化学
背景情况:
- 研究固体粒子之间的有机反应对于开发新的合成方法至关重要.
- 据报道,许多反应都发生在固体阶段,但它们的机制需要澄清.
研究的目的:
- 研究固体阶段有机反应的概念.
- 确定固体反应剂之间的反应中相变的作用.
主要方法:
- 对19个报告的"固相"有机反应进行分析.
- 固体反应物的机械混合 (研磨).
- 观察相变 (液化) 和反应动力学.
主要成果:
- 研磨固体反应物通常会形成液态相,通常是具有低于环境温度的点的高性混合物.
- 这种液化发生在催化和非催化反应中,包括阿尔多尔凝结,贝耶-维利格氧化和芳香化.
- 观察到的反应动力学是通过从固态过渡到液态过渡来解释的.
结论:
- 宏观粒子之间的真实固体相反应很少发生;液化是一个常见的现象.
- 欧特克学或学形成是理解涉及机械混合固体试剂的反应的关键.
- 涉及固体试剂的反应系统的一般模型应考虑潜在的液相形成.
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