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Updated: Jun 24, 2026

In Vitro Disassembly of Influenza A Virus Capsids by Gradient Centrifugation
07:24

In Vitro Disassembly of Influenza A Virus Capsids by Gradient Centrifugation

Published on: March 27, 2016

基于分子动力学的初始酸A/HIV-1蛋白酶分裂部位的质子化状态的分配

S Piana1, D Sebastiani, P Carloni

  • 1Scuola Internazionale Superiore di Studi Avanzati and Istituto Nazionale di Fisica della Materia, Via Beirut 2-4, 34014 Trieste, Italy.

Journal of the American Chemical Society
|September 6, 2001
PubMed
概括

这项研究挑战了先前对HIV-1蛋白质酶结构的解释,表明二质子化酸二可能比单质子化形式更有可能. 计算分析支持这种新模型,与实验性NMR数据和酶抑制机制保持一致.

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