异常加快的西甲基转移从锡在静态合:协调驱动的转移合的含义
1Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Yoshida, Kyoto 606-8501, Japan.
Journal of the American Chemical Society
|September 6, 2001
概括
这项研究引入了一种新型的催化交叉合反应,采用甲基试剂. 上的基显著增强了基基的转移,使新的化合物的高效合成.
科学领域:
- 有机金属化学 有机金属化学
- 催化剂是一种催化剂.
- 合成有机化学 合成有机化学
背景情况:
- 催化交叉合反应在有机合成中至关重要.
- 开发有效的方法来转移功能组是一个关键的挑战.
- 甲基组提供独特的合成效用,但需要有效的激活.
研究的目的:
- 开发一种新型的催化交叉合反应,使用西甲基试剂.
- 研究基对基基转移能力的影响.
- 为了证明由此产生的交叉合产品在进一步的转换中的实用性.
主要方法:
- 帕拉催化2-PyMe2SiCH2SnBu3与化的交叉合.
- 从中分析有机群体的相对转移能力.
- 通过1H NMR和X射线结晶学对 (II) 复合物的表征.
- 随后的C-Si氧化和化催化1,2-添加反应.
主要成果:
- 单独形成的2-PyMe2SiCH2转移产品 (2-PyMe2SiCH2Ar).
- 与其他有机群体相比,2-PyMe2SiCH2的转移能力明显优越,归因于-协调.
- 通过C-Si氧化成功合成初级醇 (ArCH2OH).
- 通过对碳化合物的1,2-添加,高效合成三级醇 (ArCH2C(OH) RR').
结论:
- 在上存在的基显著加速了基催化过程中基甲基的转移.
- 这种方法提供了一条有效的途径,以功能化西甲基化合物.
- 合成的产品是用于进一步合成加工的多功能中间体.
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