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急性心肌梗塞的外观程度预测了收缩功能的长期改善
K M Choi1, R J Kim, G Gubernikoff
1Feinberg Cardiovascular Research Institute, Department of Medicine, Northwestern University Medical School, Chicago, Illinois, USA.
Circulation
|September 6, 2001
概括
与对比度增强的MRI (ceMRI) 有助于预测心肌梗塞后心脏功能恢复. 在CEMRI上观察到的心肌损伤的程度表明,心脏收缩功能在心脏病发作后会有多好地改善.
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 心脏磁力共振成像 (MRI)
背景情况:
- 动物研究表明,在对比度增强的MRI (ceMRI) 上,急性心肌梗塞 (MI) 的跨壁程度预测了未来的收缩功能.
- 在心脏病发作后,ceMRI对人类的预测价值尚未完全确定.
研究的目的:
- 为了测试ceMRI可以预测急性心肌梗塞后人类患者的收缩功能改善的假设.
主要方法:
- 第一次心脏病发作的24名患者在症状出现7天内接受了cine和ceMRI.
- 8-12周后重复心脏MRI,以评估壁壁加厚和收缩功能的变化.
- 一个72段模型被用来量化心脏病发作和细分功能障碍的跨壁程度.
主要成果:
- 细分收缩功能的改善与心脏病发作的跨壁程度 (P=0.001) 相反相关.
- 峰值肌酸激酶-MB和总心脏病发作大小没有预测全球收缩功能的改善.
- 非心脏病发作或轻微心脏病发作 (<25%的壁厚) 功能障碍性心肌的程度最能预测整体改善.
结论:
- 通过ceMRI确定的心脏病发作的跨壁范围是急性心肌梗塞患者收缩功能改善的重要预测指标.
- ceMRI提供了宝贵的预后信息,以恢复心脏功能后MI.
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