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相关概念视频

Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...

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相关实验视频

Updated: Jun 8, 2026

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction
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慢性冠状动脉全封闭的微血管功能障碍.

G S Werner1, M Ferrari, B M Richartz

  • 1Clinic for Internal Medicine III, Friedrich-Schiller-University Jena, Erlanger Allee 101, Jena, Germany. gerald.werner@med.uni-jena.de

Circulation
|September 6, 2001
PubMed
概括
此摘要是机器生成的。

微血管功能障碍影响了超过一半的慢性冠状动脉全封闭 (TCO) 患者,特别是糖尿病或高血压患者. 结合冠状动脉流速储备 (CFVR) 和分流储备 (FFR) 对于TCO血管造形术后的准确评估至关重要.

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Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction
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科学领域:

  • 心血管医学 心血管医学
  • 干预心脏病学 干预心脏病学
  • 冠状动脉疾病 冠状动脉疾病

背景情况:

  • 微血管功能障碍的特征是冠状动脉流量储备减少,而无表心狭窄.
  • 这项研究调查了慢性冠状动脉全封闭 (TCOs) 中微血管功能障碍的患病率和影响.

研究的目的:

  • 为了确定TCOs中微血管功能障碍的患病率.
  • 评估微血管功能障碍与区域性心肌功能之间的关系.
  • 评估冠状动脉流速储备 (CFVR) 和部分流量储备 (FFR) 在TCOs中的实用性.

主要方法:

  • 在42名患者中,TCOs的再通道化和支架.
  • 冠状动脉流速储备 (CFVR) 用冠状动脉内多普勒测量.
  • 在27名患者的子集中记录了部分流量储备 (FFR).
  • 在21名患者中,CFVR在24小时后重新评估.

主要成果:

  • 55%的患者表现出降低的CFVR (<2.0).
  • 在一个子组中,52%的患者显示CFVR降低,FFR不显著 (>=0.75),表明微血管功能障碍.
  • 微血管功能障碍在糖尿病和/或高血压患者中更为普遍.
  • CFVR和FFR的相关性很差 (r=0.03).

结论:

  • 微血管功能障碍在TCO中很常见 (55%),无论心肌功能区域如何.
  • 糖尿病和高血压与增加的微血管功能障碍有关.
  • 单独的CFVR和FFR都不足以评估TCO中的血管形成术结果;建议进行联合评估.