在冠状动脉支架安置后,先前的细胞巨乳病毒感染和复原
F J Neumann1, A Kastrati, T Miethke
11. Medizinische Klinik, Deutsches Herzzentrum, Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, Munich, Germany.
Circulation
|September 6, 2001
概括
之前的细胞巨乳病毒 (CMV) 感染不会增加冠状动脉支架后复原的风险. 在接受支架的患者中,CMV IgG标位与更高的血管静脉复缩或目标血管再干预率无关.
科学领域:
- 心血管医学 心血管医学
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
背景情况:
- 再激活的细胞巨乳病毒 (CMV) 可能促进皮肤穿刺冠状动脉干预 (PCI) 后的新密度形成.
- 通过抑制瘤抑制蛋白p53.3,CMV可能促进细胞循环的进展.
- 在冠状动脉支架后,先前的CMV感染在静脉缩中的作用需要进行调查.
研究的目的:
- 为了研究之前的细胞巨乳病毒感染对冠状动脉支架插入后静脉复缩的作用.
- 为了确定CMV IgG标位是否与PCI后的不良结果相关.
主要方法:
- 对551名接受冠状动脉支架安置成功的患者进行前性研究.
- 测量了细胞巨乳病毒IgG标位.
- 6个月后的血管静脉复缩和1年后的目标血管再干预被评估为初级和二级终点.
主要成果:
- 62%的患者具有阳性CMVIgG标位.
- 在CMV阳性和阴性组之间,血管学复缩率没有显著差异 (28.7%与34.6%,P=0.18).
- 两组之间没有观察到晚期光线损失或目标血管再干预率的显著差异.
- 多变量分析证实CMV阳性不是复原症的预测因素 (aOR 0.78 [0.521.19]).
结论:
- 之前的细胞巨乳病毒感染似乎不会增加冠状动脉支架后复原的风险.
- 冠状动脉病毒状况不是冠状动脉支架后复原或重新干预的重要预测因素.
相关概念视频
Cell-mediated Immune Responses
Overview
Infection
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
Stages of Infection
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
Myocarditis I: Introduction
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Cytomegalovirus Disease
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Cryptococcal Meningitis
Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...


