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新型MRI对比剂用于纤维素的分子成像:对于检测易受伤害的斑块的影响

S Flacke¹, S Fischer, M J Scott

¹Radiologische Klinik, Universität Bonn, Bonn, Germany.

|September 12, 2001

概括

研究人员开发了新的纤维素向性磁性纳米粒子,用于敏感的动脉样硬化斑块的敏感分子成像. 这种新药物增强了血栓检测,可能使早期的治疗干预成为可能.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
分子成像学分子成像学

背景情况:

有裂的脆弱动脉样硬化斑块需要对血栓进行敏感检测.
一种强大的血栓特异性对比剂对于分子成像至关重要.

研究的目的:

开发和描述一种新型的接体向的偏磁分子成像剂.
评估该剂对纤维素的高度嗜好以及对活性易受损伤的斑块敏感检测的潜力.

主要方法:

配制具有不同Gd-DTPA-BOA度 (>50,000Gd(3+) 原子/粒子) 的偏磁纳米粒子.
纳米粒子和纤维素凝块向的体外表征.
在体内对狗进行评估,以评估对比度增强和信号与噪声比.

主要成果:

偏磁纳米粒子显示T1放松率与Gd-DTPA度的单调增加.
在体外,向的纤维素凝块表现出同质的T1加权对比度增强.
在体内,向血块显示出高的对比度与噪声比率,与血液和对照血块相比.

结论:

用纤维素向性磁性纳米粒子进行分子成像,可使纤维素的敏感检测和定位.
这种方法可能允许早期直接识别易受损伤的斑块.
为动脉样硬化疾病患者及时做出治疗决策提供便利.

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