在肝移植中使用mycophenolate mofetil单疗法
Lancet (London, England)
|September 18, 2001
概括
在肝移植患者中,mycophenolate mofetil单疗改善了功能衰竭,但导致了器官排斥. 该试验因高排斥率而停止,这表明与这种免疫抑制策略相关的风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植医学 移植医学
- 免疫抑制是一种免疫抑制.
背景情况:
- 慢性功能衰竭是正位体肝移植后的一个显著并发症.
- 氨酸抑制剂免疫抑制疗法经常与毒性有关.
研究的目的:
- 评估mycophenolate mofetil单疗法作为肝移植接受者与氨酸抑制剂诱导的功能衰竭的替代方案.
主要方法:
- 进行了一项随机对照试验.
- 患者在停止使用氨酸抑制剂 (环素或塔克罗利斯) 后接受了mycophenolate mofetil单疗法.
- 监测功能和排斥的迹象.
主要成果:
- 降低和停止素尿素抑制剂剂量后,功能衰竭得到改善.
- 然而,五分之三的受菌酸莫菲蒂尔单一治疗的患者经历了器官排斥.
- 拒绝事件需要在受影响的患者进行第二次移植.
结论:
- 虽然单独治疗mycophenolate mofetil可能会改善功能,但在肝移植接受者中,它具有相当大的器官排斥风险.
- 这种策略可能不适合所有需要免疫抑制肝移植后免疫抑制的患者.
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