酒精消费和静血因素:对弗雷明汉姆后代队伍的分析
K J Mukamal1, P P Jadhav, R B D'Agostino
1Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. kmukamal@caregroup.harvard.edu
Circulation
|September 19, 2001
概括
轻度至中度的酒精摄入量通过降低凝血因子,有利于血液静止. 然而,较高的酒精消费会损害纤维素分解,这表明与心血管健康存在复杂的关系.
科学领域:
- 心血管疾病的研究研究.
- 血液静止和血栓形成
- 营养流行病学 营养流行病学
背景情况:
- 与戒酒相比,适度饮酒与心血管疾病风险降低有关.
- 酒精对静血参数的影响是一个被提议的机制,但之前的研究产生了不一致的结果.
研究的目的:
- 为了研究酒精消费与血静和纤维溶解标志物之间的关联.
- 通过其对血液凝结和凝块分解的影响,澄清酒精在心血管疾病风险中的作用.
主要方法:
- 来自弗雷明汉姆后代研究的3223名健康成年人的横截面分析.
- 用于评估酒精消费的标准化问卷.
- 测量纤维素原,血粘度,·威尔布兰德因子,因子VII,等离子原激活剂抑制剂抗原-1和组织等离子原激活剂抗原水平.
主要成果:
- 轻度至中度的酒精摄入量 (每周3至21杯饮料) 与较低的纤维素素水平,血粘度,·维勒布兰德因子和因子VII相关.
- 较高的酒精消费 (7-21+饮料/周) 与纤维解质潜能受损有关,由增加的等离子素激活剂抑制剂抗原-1和组织等离子素激活剂抗原1表明.
- 葡萄酒消费呈现出降低等离子体激活剂抑制剂抗原-1水平的趋势,特别是在适度摄入水平时.
结论:
- 轻度至中度的酒精消费与凝血因子的有利变化有关.
- 过度饮酒可能会对纤维素分析功能产生负面影响.
- 这些发现支持了一个假设,即血液静止和纤维溶解活动之间的平衡调解了酒精与冠心病的复杂关联.
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